This Policy Brief summarizes up all EUCANET project findings, outcomes and suggestions. It is addressed to local, national and EU level policy makers: by highlighting main City Agencies characters it suggests a new stronger role for these organizations at EU level.All contents base on the work promoted between 2017 and 2019 by the EUCANET partnership involving researchers, scholars, practitioners and professionals from all over Europe. The collection and comparison of ongoing activities performed by City Agencies in different EU contexts show the emerging of a deeper, more articulated and often more radical discourse on urban development, calling for a definition of a new role for City Agencies as intermediate organizations positioned between the local and the EU levels. The recorded overlapping and multifaceted relationships between highly specific, place-based initiatives and the more general principles fostered by the Pact of Amsterdam, show City Agencies unexploited potential to apply, expand and disseminate the Urban Agenda for the EU.